Endocrine Abstracts

Glucocorticoids (GC) are catabolic in skeletal muscle to provide nutrients during fasting or other stressors, including inhibiting insulin-mediated glucose uptake, protein synthesis, and mitochondrial function, while stimulating proteosomal breakdown of proteins. Published work in cultured myotubes required μM GC dosing to see these effects. We found GCs to show low nM activity in myotubes by using a more physiologically relevant setting, including nutrient deprivation an...